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Real Chemistry’s weekly analysis of biopharmaceutical pricing and value news, provided free of charge.
Real Chemistry
Value Report
March 27, 2026
China Is Making Its Move in Global Pharma

China is making a pretty direct play for global drugmakers – and doing it out in the open.

Last week, Commerce Minister Wang Wentao brought together senior pharma execs, alongside PhRMA CEO Stephen Ubl, to underscore Beijing’s effort to cement biopharma as a pillar industry under its next Five‑Year Plan. In parallel meetings, Wang urged Eli Lilly to “deepen its commitment” to China, citing market access, intellectual property protections, and regulatory predictability as incentives for long‑term investment.

The outreach comes amid a profound shift in the global drug development landscape. China has rapidly emerged as a second hub of pharmaceutical innovation – no longer just a manufacturing base, but a source of early‑stage science and clinical data increasingly shaping global pipelines.

U.S. policymakers are taking note. Capitol Hill has grown unusually unified around concerns that China’s expanding footprint – spanning R&D, clinical trials and out‑licensing of novel assets – could erode U.S. leadership in the biopharma sector if left unchecked.

Yet decoupling is easier said than done. U.S. drugmakers continue to turn to China for cost‑efficient development and pipeline replenishment, even as tariffs, biosecurity legislation and geopolitical rhetoric intensify. Experts caution that trade barriers alone are unlikely to unwind deeply integrated drug supply and innovation networks and could ultimately slow progress on both sides.

The result is a new world order in biopharma: one defined less by clean separation than by strategic tension, selective collaboration and a growing imperative for policymakers to balance competition with patient access.

Stephen Tellone, Associate Director

Denali and Corcept Score FDA Approvals for First-in-Class Therapies

Following a string of rejections and requests for additional data on rare-disease therapies (as well as a moment of confusion), the FDA approved a treatment for Hunter syndrome via the accelerated pathway based on a surrogate biomarker.

Avlayah, produced by Denali Therapeutics, is the first treatment for the rare condition to address neurological symptoms. Framing the decision, FDA Commissioner Marty Makary emphasized both flexibility and rigor: The agency can accelerate rare disease treatments while still meeting the legal bar for “substantial evidence” of effectiveness.

For a weekly infusion, Denali set the list price at roughly $5,200 per vial. As with other enzyme replacement therapies, the total cost will vary by patient weight. The company also highlighted a suite of access and affordability programs, including co-pay assistance.

The FDA also granted early approval to Corcept’s Lifyorli, a first-in-class oral ovarian cancer therapy priced at $37,900 for a 28-day cycle. The company expects broad coverage across plans, including Medicare and Medicaid, and announced patient assistance programs to support access.

Leah Nebbia, Senior Group Director

To MAHA or Not to MAHA…That is the Question

The Trump administration missed a key deadline this week for nominating a new director of the CDC. As a result, Dr. Jay Bhattacharya will still effectively serve as the acting head of the CDC while pulling double duty as the NIH Director.

The lapse in permanent leadership is another marker of ongoing chaos for the administration’s health agencies. The CDC is still reeling from significant staff cuts – losing nearly 25% of its career staff – and a shooting last August at its Atlanta headquarters. A steady hand to right the ship is needed, but who the next leader will be is unclear amid a complicated political landscape ahead of the 2026 midterms.

The shortlist includes Ernie Fletcher, former governor of Kentucky and family medicine physician, and Joseph Marine, a cardiologist at Johns Hopkins Medicine. Fletcher is the traditional choice and has largely stayed away from controversial opinions. Marine, however, has questioned the use of repeated doses of COVID-19 vaccines and joined others in the MAHA movement criticizing a temporary ruling that paused HHS’ overhaul of U.S. vaccine policy.

What comes next for the high-profile role could be a bellwether for the administration’s health policy agenda to come, as it increasingly side-steps unpopular anti-vaccine stances in favor of broader messages around healthcare affordability to try and retain votes come November.

Rachel Bridges, Senior Director

Circled on Our Calendar
Quotes of the Week
  • “The question is not whether mRNA manufacturing will expand globally – it already is. The question is whether American companies will participate from facilities on U.S. soil or somewhere else. America won the race to develop mRNA medicine. Secretary Kennedy’s ideological agenda is forfeiting the prize.” – Jeff Coller, Fortune
  • “Japan’s experience should serve as a stark warning to American policymakers currently considering a ‘Most Favored Nation’ drug pricing framework that would effectively import these same price controls into the United States.” – John Stanford, BioSpace
  • “Ironically, the language of ‘gold standard science’ can make it harder to communicate uncertainty honestly…There is also a policy risk that should not be ignored. Once a single standard is named and institutionalized, it can be used to exclude evidence that does not conform to it, even when that evidence is appropriate to the question at hand.” – Jonathan Scaccia, Undark
Other News
See you next week …
–  Real Chemistry
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